90 Results for "

Vitis vinifera cv. Zalema

" in MedChemExpress (MCE) Product Catalog:
Products (90)

90 Results for "Vitis vinifera cv. Zalema" in MCE Product Catalog:

8
Eplerenone
Eplerenone
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8 Publications Verification
Cat. No.: HY-B0251
CAS No.: 107724-20-9
Synonyms: Epoxymexrenone
Category:  

Cardiovascular Disease Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Mineralocorticoid Receptor Endogenous Metabolite

Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
8
Eplerenone (Standard)
Eplerenone (Standard)
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8 Publications Verification
Cat. No.: HY-B0251R
CAS No.: 107724-20-9
Synonyms: Epoxymexrenone (Standard)
Target:  

Reference Standards Mineralocorticoid Receptor Endogenous Metabolite

Research Areas:  

Cardiovascular Disease Cancer

Eplerenone (Standard) is the analytical standard of Eplerenone. This product is intended for research and analytical applications. Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). Eplerenone also is a selective mineralocorticoid receptor antagonist (MRA) with IC50 value of 0.081 μM. Eplerenone can be used for the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
7
Candesartan
Candesartan
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7 Cited Publications
Cat. No.: HY-B0205
CAS No.: 139481-59-7
Synonyms: CV 11974
Target:  

Angiotensin Receptor PPAR

Research Areas:  

Cardiovascular Disease Endocrinology Cancer

Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) .
4
Nootkatone
Nootkatone
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4 Cited Publications
Cat. No.: HY-N2195
CAS No.: 4674-50-4
Synonyms: (+)-Nootkatone
Category:  

Terpenoids Sesquiterpenes Vitis vinifera cv. Zalema Plants Vitaceae

Target:  

Environmental Pollutants Interleukin Related TNF Receptor

Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .
3
Manidipine dihydrochloride
Manidipine dihydrochloride
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3 Cited Publications
Cat. No.: HY-17403
CAS No.: 89226-75-5
Synonyms: CV-4093
Target:  

Calcium Channel NF-κB

Research Areas:  

Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology

Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection .
1
ε-​Viniferin
ε-​Viniferin
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1 Cited Publications
Cat. No.: HY-N3841
CAS No.: 62218-08-0
Synonyms: epsilon-Viniferin
Category:  

Stilbenes Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Disease Research Fields Inflammation/Immunology

Target:  

Cytochrome P450

ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .
1
S-23
S-23
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1 Cited Publications
Cat. No.: HY-112257
CAS No.: 1010396-29-8
Purity:  99.93%
Target:  

Androgen Receptor

Research Areas:  

Metabolic Disease

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats .
1
MX1013
MX1013
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1 Cited Publications
Cat. No.: HY-10397A
CAS No.: 582316-00-5
Purity:  96.32%
Synonyms: CV1013; Z-VD-FMK
Target:  

Caspase

Research Areas:  

Cancer

MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM .
Furaneol
Furaneol
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Cat. No.: HY-N7093
CAS No.: 3658-77-3
Synonyms: Strawberry furanone
Category:  

other families Microorganisms Ketones, Aldehydes, Acids Other Diseases Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields

Target:  

Environmental Pollutants Quinone Reductase Fungal Bacterial

Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
Benazeprilat
Benazeprilat
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Cat. No.: HY-118472
CAS No.: 86541-78-8
Purity:  99.54%
Synonyms: CGS 14831
Category:  

Cardiovascular Disease Alkaloids Other Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Endogenous Metabolite Angiotensin-converting Enzyme (ACE)

Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
CV-6209
CV-6209
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Cat. No.: HY-109897
CAS No.: 100488-87-7
Purity:  ≥98.0%
Target:  

Platelet-activating Factor Receptor (PAFR)

Research Areas:  

Cardiovascular Disease

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats .
Benzylideneacetone
Benzylideneacetone
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Cat. No.: HY-W012595
CAS No.: 122-57-6
Synonyms: Benzalacetone
Category:  

Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Environmental Pollutants Antibiotic Endogenous Metabolite Phospholipase Bacterial Tyrosinase

Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods .
Loliolide
Loliolide
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Cat. No.: HY-118020A
CAS No.: 5989-02-6
Purity:  99.72%
Synonyms: Loliolid; Digiprolactone
Category:  

Natural Products Metabolic Disease Plants Compositae Millettia usaramensis Taub. Disease Research Fields

Target:  

Endogenous Metabolite Caspase PI3K Apoptosis Akt Sirtuin Reactive Oxygen Species (ROS) NF-κB MMP

Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease .
Ribulose 1,5-bisphosphate
Ribulose 1,5-bisphosphate
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Cat. No.: HY-164642
CAS No.: 24218-00-6
Synonyms: RuBP
Category:  

Natural Products Endogenous metabolite

Target:  

Endogenous Metabolite

Ribulose 1,5-bisphosphate (RUBP) is a vital photosynthetic intermediate and substrate. Ribulose 1,5-bisphosphate acts as both product and substrate for Thermococcus kodakarensis KOD1 R15Pi. Ribulose 1,5-bisphosphate tightly binds to inactive RuBP carboxylase sites in plant leaves.Ribulose 1,5-bisphosphate serves as the key substrate for CO2 fixation in photosynthesis. Ribulose 1,5-bisphosphate supports carboxylation and regeneration processes in photosynthesis. Ribulose 1,5-bisphosphate determines the dynamic transition temperature of photosynthetic control. Ribulose 1,5-bisphosphate can be used for photosynthesis and enzyme mechanism research .
AS6
AS6
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Cat. No.: HY-120161
CAS No.: 1609660-14-1
Synonyms: 3'-Hexylsulfanylabscisic acid
Target:  

ABA Receptor Phosphatase

Research Areas:  

Others

AS6 (3'-Hexylsulfanylabscisic acid) is a PYL antagonist with a Kd value of 0.48 μM for Arabidopsis PYL5. AS6 binds to PYL proteins, and its S-hexyl chain blocks PP2C binding via steric hindrance. AS6 alleviates the inhibitory effect of ABA on seed germination in Arabidopsis and lettuce .
Quinagolide hydrochloride
Quinagolide hydrochloride
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Cat. No.: HY-13736A
CAS No.: 94424-50-7
Synonyms: CV205-502 hydrochloride
Target:  

Dopamine Receptor Akt

Research Areas:  

Neurological Disease Cancer

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer .
Pirlindole
Pirlindole
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Cat. No.: HY-100679
CAS No.: 60762-57-4
Purity:  98.90%
Target:  

Monoamine Oxidase Enterovirus

Research Areas:  

Infection Neurological Disease

Pirlindole is a selective and reversible MAO-A inhibitor . Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3) .
Vitisin A
Vitisin A
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Cat. No.: HY-142026
CAS No.: 142449-89-6
Synonyms: (+)-Vitisin A
Category:  

Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae

Target:  

Caspase ERK NF-κB Influenza Virus PAK LDLR PPAR PCSK9 Androgen Receptor Keap1-Nrf2 Monoamine Oxidase Cholinesterase (ChE) IKK Wnt β-catenin Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Vitisin A ((+)-Vitisin A) is an orally active natural product with multiple pharmacological activities including anti-inflammatory, anti-tumor, anti-oxidant, anti-pathogenic microorganism, hypoglycemic and lipid-regulating, anti-osteoporotic, neuroprotective and cardiovascular protective effects. Vitisin A exhibits inhibitory effects on human AChE and MAO-B with IC50 values of 1.29 µM and 4.94 µM, respectively. Vitisin A inhibits the ERK, MAPK, NF-κB, STAT1, HMGCR and TRAF6 pathways, downregulates the related phosphorylation and protein expression, while activates the Nrf2/HO-1 pathway and upregulates p21 expression. Vitisin A induces tumor cell apoptosis and cell cycle arrest, inhibits adipogenesis and lipid accumulation, while alleviates oxidative stress, suppresses inflammatory responses, blocks hepatic fibrosis, Cuproptosis and cholesterol synthesis, and increases the expression levels of central BDNF and TrkB. Vitisin A can be used in the research of tumors, infectious diseases, metabolic diseases, bone and joint diseases, liver diseases, skin injuries, as well as neurodegenerative and cognitive dysfunction-related diseases .
Ningnanmycin
Ningnanmycin
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Cat. No.: HY-N13047
CAS No.: 156410-09-2
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

TMV SOD

Ningnanmycin is a plant antiviral agent. Ningnanmycin binds to specific residues on the TMV CP disc, inhibits CP assembly, disassembles the CP disc into monomers, and disrupts the structure of the TMV CP disc to reduce pathogenicity. Ningnanmycin binds to key amino acids of PVY CP, interferes with CP-CP interactions, inhibits CP assembly and virion formation, and blocks PVY replication. Ningnanmycin induces the expression of antiviral response genes PRXIIB, PRXIIE, PUB4 and PER42, thereby activating the host defense system. Ningnanmycin can be used in studies related to Tobacco Mosaic Virus infection and Potato Virus Y infection .
CV1808
CV1808
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Cat. No.: HY-103183
CAS No.: 53296-10-9
Purity:  98%
Synonyms: 2-Phenylaminoadenosine
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Adenosine Receptor Endogenous Metabolite

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .
Assay Types